Role of CD8 + T Cells in Murine Experimental Allergic Encephalomyelitis
- 22 May 1992
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 256 (5060) , 1213-1215
- https://doi.org/10.1126/science.256.5060.1213
Abstract
The course of experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis, is affected by immunoregulatory T lymphocytes. When animals are immunized with encephalitogenic peptide of myelin basic protein and recover from the first episode of EAE, they become resistant to a second induction of this disease. Animals depleted of CD8+ T cells by antibody-mediated clearance were used to examine the role of CD8+ T cells in EAE. These cells were found to be major participants in the resistance to a second induction of EAE but were not essential for spontaneous recovery from the first episode of the disease.Keywords
This publication has 13 references indexed in Scilit:
- Less Mortality but More Relapses in Experimental Allergic Encephalomyelitis in CD8 -/- MiceScience, 1992
- CD4−CD8− splenic T cells from lewis rats recovered from experimental autoimmune encephalomyelitis respond to encephalitogenic T cells that mediate this disorderCellular Immunology, 1991
- Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells.The Journal of Experimental Medicine, 1991
- CD4+ suppressor cells differentially affect the production of IFN-gamma by effector cells of experimental autoimmune encephalomyelitis.The Journal of Immunology, 1989
- Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtypeCellular Immunology, 1989
- Long‐term depletion of cd8+ t cells in vivo in the rat: no observed role for cd8+ (cytotoxic/suppressor) cells in the immunoregulation of experimental allergic encephalomyelitisEuropean Journal of Immunology, 1988
- Suppression of experimentally induced autoimmune encephalomyelitis by cytolytic T–T cell interactionsNature, 1988
- A suppressor T-lymphocyte cell line for autoimmune encephalomyelitisNature, 1988
- T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitisNature, 1986
- Encephalitogenic T cell clones specific for myelin basic protein. An unusual bias in antigen recognition.The Journal of Experimental Medicine, 1985