Some Effects of 1‐methyl‐2‐p‐(isopropyl‐carbamoyl)‐benzyl‐hydrazine and Mannomustine on the Metabolism of Human Erythrocytes in Vitro
- 1 December 1965
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Haematology
- Vol. 2 (4) , 288-304
- https://doi.org/10.1111/j.1600-0609.1965.tb01306.x
Abstract
During incubation of erythrocytes with Natulan® and Degranol® a depression of the concentrations of reduced glutathione and adenosine triphosphate and an increase of the osmotic fragility and the formation of methaemoglobin were demonstrated. No effect of the drugs on the activity of the enzymes glucose‐6‐phosphate‐dehydrogenase and pyruvate kinase was found. The possible significance of these findings is discussed.This publication has 30 references indexed in Scilit:
- Studies on the Osmotic Fragility of Normal Human ErythrocytesActa Medica Scandinavica, 2009
- Studies on the Osmotic Fragility of Normal Human Erythrocytes: I. A Method for the Determination of the Effect of Hypotonic SolutionsActa Medica Scandinavica, 2009
- Die Auslösung von Fenton‐Reaktionen durch cytotoxische Methylhydrazin‐VerbindungenHelvetica Chimica Acta, 1964
- METABOLIC CHANGES IN NORMAL AND GLUCOSE-6-PHOSPHATE DEHYDROGENASE-DEFICIENT ERYTHROCYTES INDUCED BY ACETYLPHENYLHYDRAZINE*Journal of Clinical Investigation, 1963
- THE EFFECT OF PHENYLHYDRAZINE ON THE ADENOSINE TRIPHOSPHATE CONTENT OF NORMAL AND GLUCOSE-6-PHOSPHATE DEHYDROGENASE-DEFICIENT HUMAN BLOOD*Journal of Clinical Investigation, 1961
- SUBSTANCES STIMULATING GLUCOSE CATABOLISM BY THE OXIDATIVE REACTIONS OF THE PENTOSE PHOSPHATE PATHWAY IN HUMAN ERYTHROCYTES*Journal of Clinical Investigation, 1961
- Role of Glutathione and of a Self-stabilizing Chain of SH-Enzymes and Substrates in the Metabolic Regulation of ErythrocytesNature, 1961
- Hereditary Absence of Reduced Glutathione in the Erythrocytes — a New Clinical and Biochemical Entity?Vox Sanguinis, 1961
- EFFECTS OF PRIMAQUINE AND OTHER RELATED COMPOUNDS ON THE RED BLOOD CELL MEMBRANE. I. NA+ AND K+ PERMEABILITY IN NORMAL HUMAN CELLS*Journal of Clinical Investigation, 1961
- THE DETERMINATION OF THE SURVIVAL OF TRANSFUSED RED CELLS BY A METHOD OF DIFFERENTIAL HEMOLYSIS 1Journal of Clinical Investigation, 1954