Etiologic Related Studies of Ultraviolet Light-Mediated Carcinogenesis
- 1 January 1976
- journal article
- research article
- Published by S. Karger AG in Oncology
- Vol. 33 (3) , 119-122
- https://doi.org/10.1159/000225124
Abstract
Comparisons were made of cholesterol-5α, 6α-epoxide (CAE) levels in skin of hairless mice maintained on a regular or antioxidant supplemented diet and receiving chronic ultraviolet light (UVL) radiation over an 18-week period. Cholesterol-5α, 6α-epoxide levels in skin of animals on antioxidant supplemented diet, while reaching a peak four weeks after that of animals on regular diet, thereafter were consistently higher. Dietary antioxidants nevertheless had an inhibitory effect on UVL-induced tumors. These data are inconsistent with the theory of CAE involvement as an ultimate carcinogen in UVL-mediated carcinogenesis.Keywords
This publication has 1 reference indexed in Scilit:
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951