Effect of Indomethacin on Renal Function and Plasma Renin Activity in Dogs with Chronic Renovascular Hypertension

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Abstract
The effect of indomethacin on plasma renin activity (PRA) and renal function was examined in conscious dogs with chronic renovascular hypertension before or after volume expansion. PRA did not change following the infusion of indomethacin: PRA was 5.18 ± 1.46 ng/ml/h during control periods and was 5.01 ± 0.95 ng/ml/h (p > 0.1) after 80 min of infusion of indomethacin. Mean arterial blood pressure (MABP) was 121.6 ± 7.4 mm Hg during control periods and was 122.0 ± 4.6 mm Hg (p > 0.1) after 80 min of infusion of indomethacin. Infusion of indomethacin into these dogs undergoing diuresis did not change inulin or p-aminohippuric acid clearance. Sodium excretion (UnaV) showed slight but not significant decreases with the infusion of indomethacin. UnaV was 109.3 ± 25.7 µEq/min during control periods and was 69.6 ± 21.0 µEq/min (0.05 < p < 0.1) after 80 min of infusion of indomethacin. The results suggest that renin release, sodium excretion, and blood pressure in the dog with chronic renovascular hypertension is uninfluenced by indomethacin.

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