Effects of vitamins A and D on the biosynthesis of l-ascorbic acid by rat-liver microsomes

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Abstract
The synthesis of L-ascorbic acid from either D-glucuronolactone or L-gulonolactone by liver microsomes of rats is decreased under conditions of hypervitaminosis A; under hypervitaminosis D the synthesis from D-glucuronolactone is increased and that from L-gulonolactone is not affected. The microsomal conversion of L-gulonolactone into L-ascorbic acid is impaired in liver tissues of rats made deficient with respect to either vitamin A or vitamin D when compared with the controls maintained on stock diet.