Role of Amino Acid Residue 187 of Poliovirus Polypeptide 2C in Determining the Guanidine Trait
- 1 January 1992
- journal article
- research article
- Published by S. Karger AG in Intervirology
- Vol. 33 (3) , 165-172
- https://doi.org/10.1159/000150246
Abstract
Although mutations in codons 164 and 179 of poliovirus polypeptide 2C can establish guanidine resistance, the majority of guanidine-resistant and guanidine-dependent viruses contain an M → L change at amino residue 187 along with other critical mutations. The change at residue 187 probably contributes to the guanidine phenotype along with a variety of other modifications in polypeptide 2C, possibly altering conformation of the polypeptide during the initiation step of viral RNA synthesis.Keywords
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