Genetic deficiency of α1‐PI in mice influences lung responses to bleomycin
Open Access
- 1 March 2001
- journal article
- Published by European Respiratory Society (ERS) in European Respiratory Journal
- Vol. 17 (3) , 474-480
- https://doi.org/10.1183/09031936.01.17304740
Abstract
It has recently been suggested that proteinase inhibitors modulate the fibrotic response in the lung. This study investigated the development of bleomycin-induced pulmonary changes in pallid mice, deficient in serum α1‐proteinase inhibitor, and with a lower elastase inhibitory capacity, and in congenic C57Bl/6J mice.Male pallid and C57Bl/6J mice received a single intratracheal instillation of either saline or bleomycin. The investigation was carried out by means of biochemical, morphological and morphometrical methods.In both strains, 21 and 72 h after bleomycin, the lungs showed foci of inflammatory cell infiltration associated with emphysema. Fibrosis developed with time after bleomycin. At 14 days fibrosis affected 23.46±9.48% (mean± sd) and 40.62±13.34% (p1‐proteinase inhibitor deficiency.Keywords
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