Quantitation of Amphetamine, Methamphetamine, and Their Methylenedioxy Derivatives in Urine by Solid-Phase Microextraction Coupled with Electrospray Ionization−High-Field Asymmetric Waveform Ion Mobility Spectrometry−Mass Spectrometry

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Abstract
Amphetamine, methamphetamine, and their methylenedioxy derivatives have been identified and measured in a human urine matrix using solid-phase microextraction (SPME) and high-field asymmetric waveform ion mobility spectrometry (FAIMS) in combination with electrospray ionization (ESI) and mass spectrometric detection (MS). Limits of detection in human urine between 200 pg/mL and 7.5 ng/mL have been achieved. The use of a simple extraction method, SPME, combined with the high sensitivity and selectivity of ESI-FAIMS-MS eliminates the need for chromatographic separation and allows for very rapid sample processing.

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