Fear-potentiated startle, but not prepulse inhibition of startle, is impaired in CREB-super(αδ-/- ) mutant mice.
- 1 January 2000
- journal article
- Published by American Psychological Association (APA) in Behavioral Neuroscience
- Vol. 114 (5) , 998-1004
- https://doi.org/10.1037//0735-7044.114.5.998
Abstract
Fear-potentiated startle was assessed in mice with a targeted disruption of the alpha and delta isoforms of the transcription factor cAMP response element binding protein (CREB) 24 hr after 5 tone + shock training trials. Whereas wild-type mice showed fear-potentiated startle that persisted up to 45 days after training, CREBalphadelta-/- mice failed to show fear-potentiated startle. However, CREBalphadelta-/- and wild-type mice had similar startle amplitudes and similar magnitudes of prepulse inhibition of startle, suggesting that CREBalphadelta-/- mice have no obvious sensory or motor deficits. These results add to the literature indicating that CREB-activated transcription plays a critical role in the formation of long-term memory and illustrate the utility of the fear-potentiated startle paradigm for assessing cognition in genetically altered mice.Keywords
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