Electron Microscopic Observations on Bone Marrow and Liver Tissue in Non-Hereditary Refractory Sideroblastic Anaemia

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Abstract
Important iron accumula-tions in the mitochondria of erythroblasts are observed. Rhopheocytosis with ferritin appears intense in erythroblasts and is also present in a part of the medullar reticulocytes. Lysis of erythroblasts is frequent. The iron of lysing cells is taken by the reticular cells. The reticular cells of bone marrow, the Kupffer cells and the liver cells are overcharged with iron. In these cells iron accumulations in mitochondria are never seen.