Heat capacity change for ribonuclease A folding
- 1 January 1999
- journal article
- Published by Wiley in Protein Science
- Vol. 8 (7) , 1500-1504
- https://doi.org/10.1110/ps.8.7.1500
Abstract
The change in heat capacity deltaCp for the folding of ribonuclease A was determined using differential scanning calorimetry and thermal denaturation curves. The methods gave equivalent results, deltaCp = 1.15+/-0.08 kcal mol(-1) K(-1). Estimates of the conformational stability of ribonuclease A based on these results from thermal unfolding are in good agreement with estimates from urea unfolding analyzed using the linear extrapolation method.Keywords
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