L‐Deprenyl in the Treatment of Mild Dementia of the Alzheimer Type: Preliminary Results
- 27 April 1993
- journal article
- clinical trial
- Published by Wiley in Journal of the American Geriatrics Society
- Vol. 41 (4) , 367-370
- https://doi.org/10.1111/j.1532-5415.1993.tb06942.x
Abstract
Objective: To examine the short‐term cognitive and behavioral effects of L‐deprenyl in persons with mild dementia of the Alzheimer type (DAT) over a 2‐month period. Design: A 15‐month randomized, double‐blind, placebo‐controlled trial using a parallel‐group design. This report deals with the first 2 months of the trial. Participants: 39 subjects with mild DAT (CDR 1) selected using NINCDS‐ADRDA criteria. Measures: A battery of neuropsychological tests and clinical rating scales. Results: The placebo and L‐deprenyl subjects were similar at baseline on the clinical and neuropsychological tests. There was no evidence of a L‐deprenyl effect on any clinical or neuropsychological measures after 2 months. Conclusion: L‐deprenyl did not have a measurable impact on behavior or cognitive function over a 2‐month period in this group of subjects with mild DAT.Keywords
This publication has 19 references indexed in Scilit:
- L-Deprenyl Therapy Improves Verbal Memory in Amnesic Alzheimer PatientsClinical Neuropharmacology, 1991
- A Pilot Study of Low-Dose L-Deprenyl in Alzheimer's DiseaseJournal of Geriatric Psychiatry and Neurology, 1991
- Effects of a MAO-B Inhibitor in the Treatment of Alzheimer DiseaseEuropean Neurology, 1991
- Neuropsychological Effects of L-Deprenyl in Alzheimerʼs Type DementiaClinical Neuropharmacology, 1990
- Effect of Deprenyl on the Progression of Disability in Early Parkinson's DiseaseNew England Journal of Medicine, 1989
- The Effect of Deprenyl (Selegiline) on the Natural History of Parkinson's DiseaseScience, 1989
- Deprenyl as Prophylaxis Against Parkinsonʼs Disease?Clinical Neuropharmacology, 1988
- L-Deprenyl in Alzheimer's DiseaseArchives of General Psychiatry, 1987
- Cognitive effects of l-deprenyl in Alzheimer's diseasePsychopharmacology, 1987
- Increased life expectancy resulting from addition of l-deprenyl to Madopar® treatment in Parkinson's disease: A longterm studyJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1985