The effects of temperature variations on cryoprecipitate

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Abstract
The effect of temperature on [human] factor VIII levels in blood and cryoprecipitate was assessed. Freshly collected units of blood required several hours to reach 4.degree. C, but this delay seemed of little importance since equal amounts of cryoprecipitated factor VIII were recovered from blood stored at 22.degree. C or at 4.degree. C. Freezing at -80.degree., -60.degree. or -40.degree. C produced identical yields of factor VIII. Freezing at -20.degree. C resulted in significantly lower recoveries. This might be expected if the physiochemical changes that occur during the freezing process are considered.