Regiospecific syntheses of modified steroid hormones. Part III. 2-Fluoro-oestrone and –17β-oestradiol
- 1 January 1972
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 2300-2302
- https://doi.org/10.1039/p19720002300
Abstract
In a regiospecific synthesis of 2-fluoro-oestrone (5), 2α-fluoro-10β-hydroxyoestr-4-ene-3,17-dione (4), obtained by cine-fluorination of 4β,5β-epoxy-10β-hydroxyoestr-4-ene-3,17-dione (3) was dehydrated with thionyl chloride in collidine. The product (5) was identical with material independently synthesized by the Schiemann-Balz reaction.Keywords
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