DOXYCYCLINE IN TREATMENT OF CHOLERA

  • 1 January 1976
    • journal article
    • research article
    • Vol. 54  (2) , 177-179
Abstract
Doxycycline was compared with tetracycline in the treatment of [human] cholera. Four types of treatment were compared: Group A was given 200 mg of doxycycline on admission and 100 mg on the 2nd day; Group B was given 200 mg of doxycycline on admission only; Group C was given 300 mg of doxycycline on admission only; and Group D received 500 mg of tetracycline every 6 h for 48 h. Tetracycline showed a slight advantage in respect of duration of diarrhea and vibrio excretion compared with doxycycline given as a single dose of 300 mg, but fluid intake and output were about the same in these 2 groups. The other 2 doxycycline treatment schedules did not compare well with tetracycline treatment.