Enzymatic in vitro reduction of ketones. Part 8. A new model for the reduction of cyclic ketones by horse liver alcohol dehydrogenase. (HLAD)
- 1 January 1982
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 2
- No. 9,p. 1123-1128
- https://doi.org/10.1039/p29820001123
Abstract
The values for the reaction rate constants of the catalytic step HLAD-NADH + ketone → HLAD-NAD++ alcohol in the HLAD-catalysed reduction of cyclic ketones are rationalized in a new model. The fundamental concepts of the model are discussed. An extensive description of the model-building is presented and its predictive value for any possible six-membered ring substrate is shown. A comparison with previous models is given.Keywords
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