Eosinophil function in eosinophil-associated gastrointestinal disorders
- 1 January 2006
- journal article
- review article
- Published by Springer Nature in Current Allergy and Asthma Reports
- Vol. 6 (1) , 65-71
- https://doi.org/10.1007/s11882-006-0013-8
Abstract
Eosinophil-associated gastrointestinal disorders (EGIDs) are characterized by a rich eosinophilic inflammation of the gastrointestinal tract in the absence of known causes for eosinophilia or other gastrointestinal disorders. These disorders include eosinophilic esophagitis, eosinophilic gastritis, eosinophilic gastroenteritis, eosinophilic enteritis, and eosinophilic colitis, and are being recognized with increasing frequency. Clinical studies suggest that eosinophils have a pathogenic role in EGID; however, the function of eosinophils in these disorders remains an enigma. In this review, we brie.y describe the clinical features of EGID of the esophagus, small bowel, and colon. We summarize recent experimental analysis examining the underlying contribution of eosinophils to disease pathogenesis and discuss possible therapeutic approaches for the treatment of these diverse diseases.Keywords
This publication has 52 references indexed in Scilit:
- Epicutaneous Antigen Exposure Primes for Experimental Eosinophilic Esophagitis in MiceGastroenterology, 2005
- Eosinophilic esophagitis is frequently associated with IgE-mediated allergic airway diseasesJournal of Allergy and Clinical Immunology, 2005
- Treatment of asthma with nebulized lidocaine: A randomized, placebo-controlled studyJournal of Allergy and Clinical Immunology, 2004
- Chemokines in asthma: Cooperative interaction between chemokines and IL-13Journal of Allergy and Clinical Immunology, 2003
- High-resolution EUS in children with eosinophilic “allergic” esophagitisGastrointestinal Endoscopy, 2003
- Eosinophilic GastroenteritisJournal of Pediatric Gastroenterology and Nutrition, 2000
- The effects of glucocorticoids on human eosinophilsJournal of Allergy and Clinical Immunology, 1994
- Ultrastructural Identification of Exocytosis of Granules from Human Gut Eosinophils in vivoInternational Archives of Allergy and Immunology, 1993
- Food allergy manifested by eosinophilia, elevated immunoglobulin E level, and protein-losing enteropathy: the syndrome of allergic gastroenteropathyJournal of Allergy and Clinical Immunology, 1982
- Neonatal eosinophilic colitisThe Journal of Pediatrics, 1982