Selective processing of β-endorphin in regions of porcine pituitary
- 1 December 1980
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 288 (5791) , 613-615
- https://doi.org/10.1038/288613a0
Abstract
The prohormone of .beta.-endorphin is unusual in that it is the precursor of more than 1 biologically active peptide. The activation of this pro hormone, to produce ACTH, .alpha.-melanotropin (.alpha.-MSH) and .beta.-endorphin, would seem to be relatively complex as its processing pattern is known to differ between tissues. ACTH is produced in the anterior pituitary whereas .alpha.-MSH is formed in the pars intermedia; lipotropin and .beta.-endorphin seem to predominate in the anterior pituitary whereas .beta.-endorphin alone is presumably the principal component in the pars intermedia. A study is reported of the distribution of .beta.-endorphin-related peptides in various regions of porcine pituitary. The main products in the anterior pituitary were lipotropin and the potent analgesic form of .beta.-endorphin; the main products in the pars intermedia were the inactive lipotropin C''-fragment and its N-acetyl derivative. The processing of the C-terminal region of the .beta.-endorphin prohormone differs markedly between the 2 regions of porcine pituitary.Keywords
This publication has 14 references indexed in Scilit:
- Influence of N-terminal acetylation and C-terminal proteolysis on the analgesic activity of β-endorphinBiochemical Journal, 1980
- DISTRIBUTION OF ADRENOCORTICOTROPHIC AND LIPOTROPHIC PEPTIDES IN THE RATJournal of Endocrinology, 1980
- Endorphins are stored in biologically active and inactive forms: isolation of α-N-acetyl peptidesNature, 1979
- Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursorNature, 1979
- Isolation of the C-fragment and C′-fragment of lipotropin from pig pituitary and C-fragment from brainBiochemical Journal, 1978
- beta-Lipotropin is the major opioid-like peptide of human pituitary and rat pars distalis: lack of significant beta-endorphin.Proceedings of the National Academy of Sciences, 1978
- Regional dissociation of beta-endorphin and enkephalin contents in rat brain and pituitary.Proceedings of the National Academy of Sciences, 1977
- C‐FRAGMENT OF LIPOTROPIN—AN ENDOGENOUS POTENT ANALGESIC PEPTIDEBritish Journal of Pharmacology, 1977
- Common precursor to corticotropins and endorphinsProceedings of the National Academy of Sciences, 1977
- The evolution of vertebrate corticotrophin and melanocyte stimulating hormoneGeneral and Comparative Endocrinology, 1975