AMINO ACID SEQUENCE SELECTION IN PROTEIN SYNTHESIS

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Abstract
One of the main problems in understanding protein synthesis is the selection of a particular sequence of amino acids; the author assumes that the essential information necessary for the formation of a (filial) protein chain is stored in a parental protein chain attached to a ribonucleic acid (RNA) chain. Sequence formation is presented as a single step phenomenon. Several schemes are proposed in which the information about a filial amino acid sequence is stored in an (unfolded) parental protein chain, the amino acid sequence constituting the essential part of the "template". Several model schemes to illustrate the application of the property of specificity of charge fluctuation forces are given. In discussing models, emphasis is placed on the problem of formation of a replica protein and detailed attention is given to schemes in which the template is an extended parental protein chain attached to a single strand extended RNA chain by hydrogen bonds. Considering what fraction of the set of parental amino acids is attached to what fraction of the set of nucleotides, only those schemes in which every monomer of the protein chain is attached to the RNA chain are discussed in detail.

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