Effects of mutations within the 3' orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity

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Abstract
Mutations that eliminated the ability of the human T-cell lymphotropic virus type III to produce the 27-kilodalton 3'' orf product did not eliminate the ability of the virus to replicate in and kill T4+ cells. A mutant carrying a mutation that deleted carboxy-terminal sequences from the envelope gene as well as the 3'' orf sequences retained the ability to kill T4+ lymphocytes, but had a retarded replication rate.