The process of infection with bacteriophage phi-X174. XXII. Synthesis of progeny single-stranded DNA.

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Abstract
That label, which, after incorporation into (RF) replicative form during the period of RF replication, persists in RF after a period of progeny single-strand DNA formation is only in the complementary strands of RF. These strands are, under some circumstances, largely closed. Label incorporated into RFII (or I) during pulses in the "late" period of single-stranded DNA synthesis is almost exclusively in viral strands, which are open. These strands in RFII have a free 3[image]OH end and the complementary strands of such RFII molecules are for the most part closed. A low rate of synthesis of complementary strands continues during the period of progeny single-strand DNA formation.