The elimination of furazolidone and its open-chain cyano-derivative from adult swine
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 17 (12) , 1427-1435
- https://doi.org/10.3109/00498258709044003
Abstract
1. A sensitive method for the determination of 3-(4-cyano-2-oxobutylidene amino)-2-oxazolidone, the open-chain cyano-derivative of the veterinary drug furazolidone, in swine plasma and tissues is described. 2. After dosing adult swine orally with furazolidone (690 mg animal per day) for 10 days no furazolidone was detected in liver, kidney and muscle (< 2 ng/g). The half life of furazolidone as measured from the terminal phase of the plasma curves was 45 minutes. In urine, small amounts (Salmonella microsome test, with or without metabolic activation.This publication has 16 references indexed in Scilit:
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