An Alternative and Efficient Synthesis of 24,24-Difluoro-1.ALPHA.,25-dihydroxyvitamin D3.

1 January 1992

journal article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 40 (5) , 1120-1124
https://doi.org/10.1248/cpb.40.1120

Abstract

An alternative synthesis of the title compound 2, a highly potent analog of 1α, 25-dihydroxyvitamin D₃ (1), is described. Starting with 1α, 3β-bis[(tert-butyldimethylsilyl)oxy]androst-5-ene (8), 2 was obtained in 3.8% total yield through 10 steps. This method provides compound 2 in much higher yield than that reported previously.

Keywords

ANALOG
BIS
TITLE
DIFLUORO
EFFICIENT
OXY
TERT
ANDROST
1.ALPHA

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