Response of Anoxic C3H Mouse Mammary Carcinoma Isotransplants (1–25 mm3) to X Irradiation2

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Abstract
First-generation isotransplants of the C3H mouse mammary carcinoma growing in the mouse ear were irradiated, under conditions of anoxia, when they were 1 to 25 mm3. The median tumor volume was 4.6 mm3, and the isotransplants were estimated to contain 6 × 106 viable cells. A dose of 4975 rads yielded a 180-day local control in one half of the tumors. D37 values (37% survival dose) for the cells of these tumors, estimated for survival fractions equivalent to 1, 10, and 100 cells after a dose of 4975 rads, ranged from 306 to 426 rads (assuming N = 2). The delay produced in the growth curve of tumors receiving 930 to 4650 rads was analyzed to determine the survival fraction of tumor. A least-squares line calculated from the survival fractions of 133 tumors (log-linear plot of survival fraction against dose) had a slope indicating a D37 value of 458 ± 44 rads; extrapolation of this line to zero dose gave a Y intercept of 2 (± 1, SE 1–4).

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