Two additional patients with thalassemia minor and ankle ulcers are reported, bringing the total number reported to ten. A genealogic study of the thalassemic trait in their family was traced. From a review of the literature it appears that all previous patients with thalassemia and leg ulcers had thalassemia minor. The composite affected patient is a 26-year-old Italian-decended woman with splenomegaly and a hemoglobin of about 8 gm/100 ml. The pathogenesis of the ulcers is nonspecific. Treatment is that of a stasis ulcer.