Diazepam Treatment Does Not Influence the Debrisoquine or Mephenytoin Hydroxylation Phenotyping Tests
- 1 November 1989
- journal article
- research article
- Published by Wolters Kluwer Health in Therapeutic Drug Monitoring
- Vol. 11 (6) , 721-723
- https://doi.org/10.1097/00007691-198911000-00019
Abstract
Debrisoquine and S-mephenytoin hydroxylation phenotyping tests were performed in 9 patients before and during treatment with diazepum at a daily dose of 10 or 15 mg. There was no change in either the debrisoquine/4-hydroxydebrisoquine ratio or the ratio of S/R mephenytoin in urine. The hydroxylation of these two test drugs is apparently not inhibited by administration of therapeutic doses of diazepam.This publication has 10 references indexed in Scilit:
- Importance of genetic factors in the regulation of diazepam metabolism: Relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotypeClinical Pharmacology & Therapeutics, 1989
- Polymorphic debrisoquin hydroxylation in 757 Swedish subjectsClinical Pharmacology & Therapeutics, 1988
- OXIDATIVE-METABOLISM OF HEXOBARBITAL IN HUMAN-LIVER - RELATIONSHIP TO POLYMORPHIC S-MEPHENYTOIN 4-HYDROXYLATION1988
- Extensive Metabolizers of Debrisoquine Become Poor Metabolizers during Quinidine TreatmentBasic & Clinical Pharmacology & Toxicology, 1987
- Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphismEuropean Journal of Clinical Pharmacology, 1986
- Stereoselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylationClinical Pharmacology & Therapeutics, 1985
- INVITRO INHIBITION STUDIES OF 2 ISOZYMES OF HUMAN-LIVER CYTOCHROME-P-450 - MEPHENYTOIN PARA-HYDROXYLASE AND SPARTEINE MONOOXYGENASE1985
- Mephenytoin hydroxylation deficiency in Caucasians: Frequency of a new oxidative drug metabolism polymorphismClinical Pharmacology & Therapeutics, 1984
- Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in manEuropean Journal of Clinical Pharmacology, 1984
- Direct enantiomeric resolution of mephenytoin and its N-demethylated metabolite in plasma and blood using chiral capillary gas chromatographyJournal of Chromatography B: Biomedical Sciences and Applications, 1983