Displacement of One Drug by Another from Carrier or Receptor Sites

  • 1 November 1965
    • journal article
    • Vol. 58  (11 Pt 2) , 946-955
Abstract
The medium of drug transfer is the water of plasma and extracellular fluid. Without complicating factors, the level of drug at a receptor site would be equal to that in the tissues and in plasma, and in dynamic equilibrium. Actually, almost all drugs are reversibly bound to proteins in plasma or tissue. The bound drug, often a high proportion of the total, acts as a reservoir, preventing wild fluctuations between ineffective and toxic levels of the biologically active unbound fraction.

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