Urinary concentration of a specific peptide of type I collagen of bone (CrossLapsTM): correlation to hydroxyproline
- 1 January 1995
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Clinical and Laboratory Investigation
- Vol. 55 (2) , 187-192
- https://doi.org/10.3109/00365519509089612
Abstract
Urinary bone resorption markers, CrossLaps and hydroxyproline are compared in a non-selected group of 93 women. The correlation between CrossĹaps and hydroxyproline is satisfactory. The r value is 0.79. Furthermore, it is investigated whether CrossLaps can substitute for hydroxyproline in the estimation of bone loss, using a model based on the combination of several biochemical markers. The results indicate that the two systems reflect related or parallel events, and show that CrossLaps is suitable for use in a normal clinical chemistry laboratory.Keywords
This publication has 19 references indexed in Scilit:
- Biochemical markers of bone turnover I: Theoretical considerations and clinical use in osteoporosisThe American Journal of Medicine, 1993
- A specific immunoassay for monitoring human bone resorption: Quantitation of type I collagen cross-linked N-telopeptides in urineJournal of Bone and Mineral Research, 1992
- Role of peak bone mass and bone loss in postmenopausal osteoporosis: 12 year study.BMJ, 1991
- Screening procedure for women at risk of developing postmenopausal osteoporosisOsteoporosis International, 1990
- PREDICTION OF RAPID BONE LOSS IN POSTMENOPAUSAL WOMENThe Lancet, 1987
- An easy and reliable method for determination of urinary hydroxyprolineClinica Chimica Acta; International Journal of Clinical Chemistry, 1984
- Pro—Gln: The procollagen peptidase cleavage site in the α1 (I) chain of dermatosparactic calf skin procollagenFEBS Letters, 1978
- Bone remodeling and calcium metabolism: A correlated histomorphometric, calcium kinetic, and biochemical study in patients with osteoporosis and Paget's diseaseMetabolism, 1977
- Urinary excretion of hydroxylysine and its glycosides as an index of collagen degradation.Journal of Clinical Investigation, 1977
- Isotopic Studies on Collagen Degradation and the Urine Excretion of Hydroxyproline *Journal of Clinical Investigation, 1964