Radiation Effects on Osteoblasts In Vitro
Open Access
- 1 September 2000
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery
- Vol. 126 (9) , 1124-1128
- https://doi.org/10.1001/archotol.126.9.1124
Abstract
OSTEORADIONECROSIS is a complication of radiation therapy for carcinoma of the head and neck that occurs in 3% to 10% of irradiated patients. Its pathogenesis has been classically described as a progression of irradiation, trauma, and infection.1 Several theories exist about its etiology. Osteoradionecrosis has been attributed to radiation fibrosis of small blood vessels. An increased incidence of osteoradionecrosis has likewise been associated with dental caries within the field of irradiated bone. The risk of bone necrosis is believed to be related to the amount of radiation, although the injury does not always occur at the area of highest dosage.2Keywords
This publication has 1 reference indexed in Scilit:
- The effect of cobalt-60 irradiation on monkey mandiblesOral Surgery, Oral Medicine, Oral Pathology, 1979