Surgical Complications Associated With Sentinel Lymph Node Dissection (SLND) Plus Axillary Lymph Node Dissection Compared With SLND Alone in the American College of Surgeons Oncology Group Trial Z0011
Top Cited Papers
- 20 August 2007
- journal article
- research article
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 25 (24) , 3657-3663
- https://doi.org/10.1200/jco.2006.07.4062
Abstract
Purpose The American College of Surgeons Oncology Group trial Z0011 was a prospective, randomized, multicenter trial comparing overall survival between patients with positive sentinel lymph nodes (SLNs) who did and did not undergo axillary lymph node dissection (ALND). The current study compares complications associated with SLN dissection (SLND) plus ALND, versus SLND alone. Patients and Methods From May 1999 to December 2004, 891 patients were randomly assigned to SLND + ALND (n = 445) or SLND alone (n = 446). Information on wound infection, axillary seroma, paresthesia, brachial plexus injury (BPI), and lymphedema was available for 821 patients. Results Adverse surgical effects were reported in 70% (278 of 399) of patients after SLND + ALND and 25% (103 of 411) after SLND alone (P ≤ .001). Patients in the SLND + ALND group had more wound infections (P ≤ .0016), seromas (P ≤ .0001), and paresthesias (P ≤ .0001) than those in the SLND-alone group. At 1 year, lymphedema was reported subjectively by 13% (3...Keywords
This publication has 30 references indexed in Scilit:
- Long term treatment related upper limb morbidity and quality of life after sentinel lymph node biopsy for stage I or II breast cancerEuropean Journal of Surgical Oncology, 2006
- Surgical Complications Associated With Sentinel Lymph Node Biopsy: Results From a Prospective International Cooperative Group TrialAnnals of Surgical Oncology, 2006
- Objective and Subjective Upper Body Function Six Months Following Diagnosis of Breast CancerBreast Cancer Research and Treatment, 2005
- Post-operative arm morbidity and quality of life. Results of the ALMANAC randomised trial comparing sentinel node biopsy with standard axillary treatment in the management of patients with early breast cancerBreast Cancer Research and Treatment, 2005
- Comparative Morbidity of Axillary Lymph Node Dissection and the Sentinel Lymph Node TechniqueAnnals of Surgery, 2004
- An audit of the incidence of arm lymphoedema after prophylactic level I/II axillary dissection without division of the pectoralis minor muscleThe Annals of The Royal College of Surgeons of England, 2003
- Prognostic factors for lymphedema after primary treatment of breast carcinomaCancer, 2001
- Lymphatic Mapping and Sentinel Lymphadenectomy for Breast CancerAnnals of Surgery, 1994
- Ten-Year Results of a Randomized Clinical Trial Comparing Radical Mastectomy and Total Mastectomy with or without RadiationNew England Journal of Medicine, 1985
- CANCER RESEARCH CAMPAIGN (KING'S/CAMBRIDGE) TRIAL FOR EARLY BREAST CANCER A Detailed Update at the Tenth YearThe Lancet, 1980