SODIUM SULFATHIAZOLE IONTOPHORESIS
- 1 August 1942
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 28 (2) , 205-213
- https://doi.org/10.1001/archopht.1942.00880080023002
Abstract
Experimentally, the bacteriostatic effectiveness of sulfathiazole (2-[paraaminobenzenesulfonamido]-thiazole) in vitro is equal to,1and in many instances greater than,2that of sulfanilamide and other derivatives against infections produced by such organisms as Staphylococcus aureus,3Bacillus proteus,1aStreptococcus (hemolytic),4Pneumococcus5(types I, II and III)5and Gonococcus.2a It is reasonable to expect satisfactory clinical results in ophthalmology if an adequate concentration of the drug can be introduced into the ocular fluids and tissues. The experiments of Bellows and Chinn and others6have shown that oral therapy is inadequate. As far as is known, the local application of sulfathiazole has not been investigated experimentally.7 The local application of other compounds of the group has met with limited experimental success. Except in the case of sulfanilamide, the concentrations obtained in the eye were too low to be of clinical value. Mengel7aobtained aKeywords
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