REGIONAL VASODILATING AND CARDIAC EFFECTS OF NICARDIPINE IN ANESTHETIZED OPEN CHEST DOG

  • 1 January 1985
    • journal article
    • research article
    • Vol. 273  (2) , 226-236
Abstract
The effects of i.v. nicardipine on the cardiovascular system in anesthetized open-chest dogs were assessed. In the dose range of 3-30 nmol/kg it induced a dose-dependent and long-lasting reduction of the vertebral, coronary and femoral vescular resistance. Nicardipine proved to be equipotent, but longer lasting than nifedipine, and .apprx. 10 and 100 times more potent than verapamil and papaverine, respectively. Unlike papaverine, Ca entry blockers caused a preferential vasodilation of the vertebral and coronary arteries. Hypotension and a reduction of LVSP [left ventricle systolic pressure] and dP/dt [change in pressure/change in time ] appeared only at the highest dose tested. For both dihydropyridine derivatives, in contrast to verapamil, the cardiodepressant effects were short-lived and resulted less marked for nicardipine than for nifedipine.

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