Sleep as a fundamental property of neuronal assemblies
Top Cited Papers
- 5 November 2008
- journal article
- review article
- Published by Springer Nature in Nature Reviews Neuroscience
- Vol. 9 (12) , 910-919
- https://doi.org/10.1038/nrn2521
Abstract
Sleep is a fundamental property of neuronal assemblies such as cortical columns. Sleep is regulated in a neuronal-assembly use-dependent manner. The mechanisms that underlie neuronal-assembly sleep include enhanced activity of sleep-regulatory substances, induced by neuronal use-enhanced metabolism. A mathematical model of loosely connected neuronal assemblies shows that they synchronize their sleep-like and awake-like states. Sleep probably evolved from a metabolically quiescent rest state. Sleep seems to function to stabilize instinctual and learned memories.Keywords
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