The antidepressant efficacy of zimelidine and maprotiline

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Abstract
In a double‐blind group comparison study of 39 patients with primary depressive illness zimelidine in a dose of 200 mg at night demonstrated the same order of antidepressant efficacy as maprotiline in a dose of 150 mg at night after either two or four weeks treatment measured by the amelioration or final score on the Hamilton Rating Scale (HRS) and on the Montgomery & Åsberg Depression Rating Scale (MADRS).Both zimelidine and maprotiline demonstrated significant antidepressant activity at 2 weeks compared with 2 weeks prior treatment with placebo measured by amelioration on HRS (paired t 4.1 P < 0.001, t 2.7 P < 0.02) or MADRS (paired t 3.5 P < 0.005, t 5.1 P < 0.001).An item analysis of the MADRS showed significantly better sleep and appetite in the maprotiline‐treated group compared with the zimelidinetreated group which is in accord with the pharmacology of the two compounds.

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