Electron spin resonance study of changes during development of solid yoshida tumour. II. Paramagnetic metal ions

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Abstract
ESR spectroscopy was used to examine changes in the concentrations of paramagnetic metal ions in Yoshida tumors in female Wistar rats. Blood, spleen and lymph nodes from these animals were also examined by ESR. A decrease in the concentration of a paramagnetic species associated with mitochondrial activity, and marked increases in those thought to be associated with inflammatory or immune reactions and cell lysis, were observed in the tumors within 1 day of implantation. During development of the tumor, and during regression after treatment with methylene dimethane sulfonate (MDMS), further changes were observed in the concentrations of the species. These were dependent on the region of the tumor examined. In blood, development of the tumor produced an increase in ceruloplasmin and a decrease in Fe transferrin. An increase in spleen weight, as the tumor developed, was accompanied by a small decrease in the concentration of species with g-values of 6.0 and 4.3, which was reversed on regression of the treated tumor. The presence of metastases in the regional lymph nodes produced readily distinguishable changes in their ESR spectra.