Malonaldehyde formation in intact platelets is catalysed by thromboxane synthase
- 15 November 1978
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 176 (2) , 595-598
- https://doi.org/10.1042/bj1760595
Abstract
Imidazole and compound L8027 (selective inhibitors of thromboxane synthase) produced parallel inhibition of malonaldehyde and thromboxane B2 secretion induced by collagen or thrombin in gel-filtered suspensions of human platelets. Comparing the effects of these inhibitors and aspirin on secretion of granule constituents indicated that platelet degranulation depends mainly on thromboxane production; prostaglandin endoperoxides contributed little.This publication has 16 references indexed in Scilit:
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