Dose-response Curves of Toxic and Infective Actions of Adenovirus in HeLa Cell Cultures

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Abstract
SUMMARY: Study of the dose-response curves in titrations of adenovirus type 5 in cultures of HeLa cells suggests two different mechanisms of cytopathic effect. A late effect, caused by relatively small virus doses, is considered to be a manifestation of virus infectivity and is in good agreement with the hypothesis of independent action of virus units in the initiation of infection. The early effect, on the other hand, requires large virus doses and is considered to be of a toxic nature. Infective and toxic properties of adenovirus type 5 are distinguished by the greater sensitivity of the latter to inactivation by ultraviolet light.