Major Congenital Malformations after First-Trimester Exposure to ACE Inhibitors
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Open Access
- 8 June 2006
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 354 (23) , 2443-2451
- https://doi.org/10.1056/nejmoa055202
Abstract
Use of angiotensin-converting–enzyme (ACE) inhibitors during the second and third trimesters of pregnancy is contraindicated because of their association with an increased risk of fetopathy. In contrast, first-trimester use of ACE inhibitors has not been linked to adverse fetal outcomes. We conducted a study to assess the association between exposure to ACE inhibitors during the first trimester of pregnancy only and the risk of congenital malformations.Keywords
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