Beta Camera Low Activity Tumor Imaging
- 1 January 1993
- journal article
- Published by Taylor & Francis in Acta Oncologica
- Vol. 32 (7-8) , 869-872
- https://doi.org/10.3109/02841869309096148
Abstract
A new technique, the beta camera, to complement film autoradiography, with fast quantitative imaging of beta particle-emitting radionuclides has been developed. It consists of a thin plastic scintillator and a light-sensitive microchannel plate detector. The thin tissue sample is mounted on the scintillator. Our first system had a high background and a moderate spatial resolution of 900 microns. We now report an improved system with a photomultiplier tube mounted on the scintillator of the microchannel plate detector. Only events registered by both detectors are accepted. A fast coincidence unit processes the signals, and if a time overlap exists, an event is generated in the beta camera. In the coincidence mode, images with low activity distribution of 201Tl (count rate 1 s-1) in 50 microns-thick slices of a human glioma tumor could be recorded with a spatial resolution of 500 microns.Keywords
This publication has 5 references indexed in Scilit:
- Localized beta dosimetry of 131 I ‐labeled antibodies in follicular lymphomaMedical Physics, 1992
- Imaging detector for static and dynamic studies in biological samplesNuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1991
- Development of a digital imaging detector based on microchannel plates for biomedical samples emitting uncharged and charged particlesNuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1988
- Dose planning with spectInternational Journal of Cancer, 1988
- Scintigraphic method to quantify the passage from brain parenchyma to the deep cervical lymph nodes in ratsEuropean Journal of Nuclear Medicine and Molecular Imaging, 1987