Metoclopramide as Prophylaxis for Nausea and Vomiting Induced by Fluorescein

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Abstract
• Fluorescein angiography carries with it a variable incidence of nausea and vomiting. We investigated a method of prophylaxis against this side effect. One hundred patients undergoing fluorescein angiography were pretreated in a doublemasked, randomized fashion with either 20 mg of intravenous metoclopramide hydrochloride or an equal volume of normal saline soution. The metoclopramidetreated group demonstrated a statistically significant decrease in the incidence of nausea and vomiting. Eleven (22%) of the control group and three (6%) of the metoclopramide-treated group had this complication. Metoclopramide is an effective drug when used prophylactically in selected patients undergoing fluorescein angiography.