Interferons induce accumulation of diadenosine triphosphate (Ap3A) in human cultured cells
- 26 February 1996
- journal article
- Published by Wiley in FEBS Letters
- Vol. 381 (1-2) , 32-34
- https://doi.org/10.1016/0014-5793(96)00073-7
Abstract
After incubation of human monocytes J96 and human myeloid leukemia HL60 cells with interferons (IFN) α or γ, the Ap3A concentration considerably increases in parallel with accumulation of tryptophanyl‐tRNA synthetase (TrpRS, EC 6.1.1.2) The Ap3A formation in response to IFNs is catalysed by an excessive amount of TrpRS. Although the Ap3A function still remain unknown its accumulation may imply the Ap3A involment in the IFN‐signalling pathway.Keywords
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