A Potent and Highly Selective Sulfotransferase Inhibitor
- 13 November 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 124 (49) , 14524-14525
- https://doi.org/10.1021/ja021086u
Abstract
In the present work, we have used a newly developed, fluorescence-based assay to screen a library of >30 000 compounds as potential β-arylsulfotransferase-IV inhibitors. A total of 11 inhibitors were discovered. Most of the compounds discovered showed low micromolar inhibition, but one of the compounds showed potent inhibition (Ki = 96 nM). The most potent of these inhibitors was tested against a variety of other purine binding enzymes and showed remarkable specificity.Keywords
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