The Crystal and Molecular Structure of the Thallium Salt of Antibiotic-6016

Publisher Website
Google Scholar
Abstract
Antibiotic-6016 is a new polyether ionophore produced by Streptomyces sp. The crystal and molecular structure of its thallium salt has been established by a three dimentional X-ray analysis using the heavy-atom method from diffractometer data. Crystals are orthorhombic, space group P212121, a = 18.767, b = 22.671, c = 12.402 Å, Dm = 1.37 (flotation in aqueous KI), Dc = 1.38 g cm−3, Z = 4. The structure was refined by block-diagonal least-squares method to R = 0.056 for 3771 independent observed reflections. The antibiotic molecule contains seven ring system: three five-membered rings take an envelope conformation, while the remaining four six-membered rings adopt a chair conformation. The molecule wraps around the thallium ion. Antibiotic-6016 is the first recognized glycosidated polyether containing the hydroxyl substituent at C2 and the sugar group at the five-membered ring D.