Fluid Dynamics in Volumogenic Diarrhea

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Abstract
A study was performed to evaluate motility patterns and the role of intestinal sphincters in a diarrhea model. Fluid was infused into the canine duodenum to produce diarrhea. We discerned 4 patterns of action in the development of volumogenic diarrhea: 1. the anal sphincter was open and the ileocecal sphincter prevented diarrhea, 2. the ileocecal and anal sphincters acted independently both preventing diarrhea to some extent, 3. the ileocecal sphincter was open and the anal sphincter prevented diarrhea, and 4. diarrhea occurred when the ileocecal sphincter was closed because of spontaneous colonic motility. Pattern 3 occurred most frequently. Duplication of these patterns was accomplished with a physical analogue constructed from Penrose tubing and clamps to simulate the intestines and the sphincters.

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