Iron-Catalyzed Kharasch-Type Reaction Between Grignard Reagents and Allylic Phosphates.Highly SN2 Selective Cross-Coupling Process
- 1 January 1991
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1991 (07) , 513-514
- https://doi.org/10.1055/s-1991-20783
Abstract
Treatment of primary allylic phosphates in tetrahydrofuran with Grignard reagents in the presence of an iron catalyst gave cross-coupling products with high SN2 selectivity. Among several phosphate leaving groups, diphenylphosphate ester showed the highest regioselectivity.Keywords
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