Penicillin in Sickle Cell Anemia

Publisher Website
Google Scholar
Abstract
Ideally, antibiotic prophylaxis should prevent disease caused by virulent organisms in immunodeficient patients. Antibiotics may interrupt the initial nasopharyngeal colonization or prevent the primary bacteremia and ensuing metastatic infection. The predilection for severe and frequent pneumococcal infections in children with sickle cell anemia, the critical link to the early loss of splenic function, and the age-adjusted prevalence rates have been amply emphasized by previous investigations.1-3 Unaccountably, the risk of pneumococcal septicemia is much higher in the young child with sickle cell anemia than in children of comparable age who have undergone simple splenectomy. In children with sickle cell anemia, the risk of pneumococcal septicemia is highest before the age of 3 years. Unfortunately, this is the same age at which multivalent pneumococcal vaccines do not reliably induce protective antibodies. Furthermore, in young children, it is not clear whether vaccines alter the nasopharyngeal carrier rate.3 Thus, the pneumococcal vaccines

This publication has 3 references indexed in Scilit: