NEOPTERIN AS DISCRIMINATING AND PROGNOSTIC PARAMETER IN HEALTHY HOMOSEXUALS, ARC AND AIDS PATIENTS

  • 7 August 1987
    • journal article
    • research article
    • Vol. 99  (15) , 531-535
Abstract
Urinary neopterin, a sensitive marker for activation of cell mediated immunity, is compared to clinical and laboratory dat in 5 patients with AIDS, in 15 patients with ARC and in 40 male subjects without AIDS-related clinical signs attending an AIDS outpatient clinic. The sensitivity of neopterin for AIDS-related diseases was higher than that of the CD4+/CD8+ subset ratio. The differences in neopterin levels between the controls, ARC and AIDS patients were found to be more significant than the T-cell subset data. The observation that the 3 AIDS patients with the highest neopterin levels have died whereas the two other with the lower levels are still alive also underlines the prognostic potential of urinary neopterin level determinations. Measurement of urinary neopterin is thus recommended as a additional criterion for monitoring ARC and AIDS patients.

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