A STUDY OF.THE MECHANISM WHEREBY COPPER ACETATE AND CERTAIN DRUGS PRODUCE OVULATION IN THE RABBIT1

Publisher Website
Google Scholar
Abstract
Ten or 15 mgs. of Cu acetate injected intraven. produced ovulation in normal unanesthetized rabbits, in normal rabbits anesthetized with nembutal and in animals which were subjected to bilateral ablation of the superior cervical ganglia. Rabbits in which the hypophysial stalk was transected 30 days or more previously failed to ovulate as a result of Cu acetate injs. Transection of the hypophysial stalk immediately before inj. of the Cu salt or at any time during the following 90 mins. likewise prevented ovulation. Convulsive doses of picrotoxin and metrazol induced ovulation in not more than half of the normal rabbits injected. Stalk-cut preps. failed to ovulate when comparable amts. of these drugs were administered. Strychnine sulfate, insulin, benzedrine and ephedrine, though given in large quantities failed to initiate ovulation. The drugs which tend to produce ovulation, apparently have a direct effect on C. N. S. centers which normally participate in the ovulatory response to coitus.