Bile acids in maternal serum, umbilical cord serum and amniotic fluid of healthy women, women with pruritus and patients with intrahepatic cholestasis of pregnancy

Publisher Website
Google Scholar
Abstract
Summary Cholic acid (CA), chenodeoxycholic acid (CDCA) and deoxycholic acid (DCA) concentrations were measured by radio-immunoassays in control subjects, in women with pruritus in pregnancy without an apparent liver disorder and in patients with intrahepatic cholestasis of pregnancy. In controls and in women with pruritus, primary bile acid (CA and CDCA) levels were higher (P < 0•01) in fetal cord serum than in maternal serum. In patients with intrahepatic cholestasis of pregnancy, CA and CDCA levels were 2-10 times higher in all compartments than in controls, except for the levels of CDCA in the amniotic fluid, which did not differ. In patients with cholestasis of pregnancy, there were more cases of fetal distress, earlier delivery times (P 50/μmol/l) and in fetal cord serum; (> 25/μmol/l) were associated with diminished fetal well-being.

This publication has 9 references indexed in Scilit: