Microsomal metabolites of the aryl hydrocarbon hydroxylase and tumour inhibitor 7,8-benzoflavone

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Abstract
Microsomal metabolism of 7,8-benzoflavone yielded three main metabolites, identified largely on the basis of nuclear magnetic resonance and mass spectral studies as the 5,6-epoxide, 9,10-dihydro-9,10-dihydroxy, and 5-hydroxy derivatives. Like BF itself, both the epoxide and the diol inhibit enzymatic aryl hydroxylation.